It's easy mate. But for this one-off I will not print as it would not be cost effective. This is how I do it in the modeling world of product design.
You have to visualise the design in layers - but in reverse of the way you normally think of them. On top is the clear sheet material. Then first level down is the black and white lettering. then the orange lines and blocking, then finally the black background. Instead of screen printing I use dry rubdown transfers. I make an artwork for each of the colours, (in Illustrator), and then I send them to one of the many companies that specialise in packaging mock-ups - this is the one I use.
http://www.main-titles.co.uk/Remember the most important thing is to get them to either put the rubdown glue surface over the TOP of the colour or make your artwork in REVERSE. Other wise your design and type will be the wrong way round. Specify the colours from a Pantone book. 24 hour turn around usually.
Then you carefully apply each layer of colour onto the back of the Perspex. It helps if you have made some registration marks on each of the artworks which helps a lot in getting the registration correct. You do not have many chances at repositioning these transfers and small type can easily get stuck and come off in the wrong position. Always get a spare set of each sheet. If it goes wrong then lighter fluid will get everything off again.
When all the transfers are down then, (on this particular screen design), I will have to mask off the places where the screen and gear indicator are placed and I want to remain clear. When this is done the last thing is to spray the whole back surface with black paint. Don't over do the paint as it may start to dissolve the transfer material - just build up the layers. Doesn't matter what finish the paint surface is - what you're trying to do is to seal on the transfers. When you turn it over and see the paint finish through the Perspex it will be amazing and perfect and shiny. Like an i phone. And all the layers of transfers will be miraculously sealed between the black paint and the bottom of the Perspex. The depth of the Persex has a strange effect on the type and design - the thicker it is the more this effect. It's a bit three dimensional - looks good.
This is when you realise there is a letter missing from one of the words or there is a small fly also captured under the paint. Time to start again
Not sure about the "roll" indicator marks yet! Will think about it as the project develops - maybe a bit too gimmicky for me, like the wear marks on Metzler M5 tyre edges. Couldn't resist seeing what it looked like though.